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Portrait of Othman Ghribi, PhD.

Othman Ghribi, PhD.

  • Professor, Biomedical Sciences
    • Alzheimer's disease; Parkinson's disease; Role of environmental, genetic and dietary factors in health and diseases; Insulin signaling; Oxidative Stress

Contact Info

  • Email: othman.ghribi@UND.edu
  • Office: 701.777.2522
  • Dept: 701.777.0385

Office Address

School Of Medicine And Health Sciences Room W234
1301 N Columbia Rd Stop 9037
Grand Forks, ND 58202-9037

Courses

BIMD 502 Scientific Discovery II

BIMD 524 Neurodegenerative Diseases and Pathophysiology

BIMD501/502 Course Director

PPT492

Curriculum Vitae

Biography

Othman Ghribi has completed his Ph.D in Neuropharmacology in 1994 at the University René Descartes, Paris France, and postdoctoral studies from The University of Quebec (1996-1999). Dr Ghribi then joined the Department of Pathology at the University of Virginia (1999-2004) and the Department of Pharmacology, Physiology, and Therapeutics (Basic Sciences currently) at the University of North Dakota School of Medicine in 2004.  He has published more than 77 papers and is serving on the Editorial Board of 13 journals including The Journal of Alzheimer’s Disease, Current Alzheimer’s disease, BMC Neuroscience, and the Journal of Neurodegenerative Diseases. Dr. Ghribi’s current research is funded by the National Institute of Health and focuses on the role of the interactions of environmental factors (chemical and dietary) with genetic susceptibility in the pathophysiology of Alzheimer’s and Parkinson’s diseases. He specifically focuses on the potential role of endoplasmic reticulum stress and lipid dyshomeostasis in inducing neurodegeneration.

a.       Papers (peer-reviewed; h factor: 29)

   1.   Lekieffre,D., Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1992) Involvement of glutamic acid and adenosine in the consequences of forebrain ischemia in the rat. Circulation et Metabolisme du Cerveau 9, 31-46.

   2.   Lekieffre,D., Ghribi,O., Callebert,J., Allix,M., Plotkine,M., & Boulu,R.G. (1992) Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia. Brain Research 592, 333-337.

   3.   Beaudeux,C., Dumortier,G., Ghribi,O., & Degrassat,K. (1993) Dispensing clozapine at the specialized hospital of Ville-Evrard: Report of seven hematological side effects. Journal de Pharmacie Clinique 12, 312-313.

  4.        Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1994) Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia. NeuroReport 5, 1253-1255.

   5.   Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1994) Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum. NeuroReport 5, 435-437.

   6.   Ghribi,O., Callebert,J., Plotkine,M., & Boulu,R.G. (1994) L-NAME modulates glutamate accumulation induced by K+-depolarization but not by forebrain ischaemia in the rat striatum. Neuroscience Letters 174, 34-38.

   7.   Ghribi,O., Callebert,J., Verrecchia,C., Plotkine,M., & Boulu,R.G. (1995) Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation m striatum during forebrain ischaemia in rats. Fundamental and Clinical Pharmacology 9, 141-146.

   8.   Dumortier,G., Lochu,A., De Melo,P.C., Ghribi,O., Rabreau,D.R., Degrassat,K., & Desce,J.M. (1996) Elevated clozapine plasma concentrations after fluvoxamine initiation [12]. American Journal of Psychiatry 153, 738-739.

   9.   Feldman,D., Ghribi,O., Ouary,J., Dumortier,G., Degrassat,K., & Leverge,R. (1998) Quality control of 7 drugs unit doses. Journal de Pharmacie Clinique 17, 268-271.

10.   Krzywkowski,P., Ghribi,O., Gagne’,J., Chabot,C., Kar,S., Rochford,J., Massicotte,G., & Poirier,J. (1999) Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice. Neuroscience 92, 1273-1286.

11.   Ghribi,O., Lapierre,L., Girard,M., Ohayon,M., Nalbantoglu,J., & Massicotte,G. (1999) Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein. Hippocampus 9, 201-205.

12.   Furling,D*., Ghribi,O*., Lahsaini,A., Mirault,M.E., & Massicotte,G. (2000) Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 97, 4351-4356. * Both authors contributed equally.

13.   Cyr,M., Ghribi,O., & Di Paolo,T. (2000) Regional and selective effects of oestradiol and progesterone on NMDA and AMPA receptors in the rat brain. Journal of Neuroendocrinology 12, 445-452.

14.   Valastro,B., Ghribi,O., Poirier,J., Krzywkowski,P., & Massicotte,G. (2001) AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice. Neurobiology of Aging 22, 9-15.

15.   Ghribi,O., DeWitt,D.A., Forbes,M.S., Herman,M.M., & Savory,J. (2001) Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: Changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits. Brain Research 903, 66-73.

16.   Ghribi,O., DeWitt,D.A., Forbes,M.S., Arad,A., Herman,M.M., & Savory,J. (2001) Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits. Journal of Alzheimer's Disease 3, 387-391.

17.   Savory,J., Ghribi,O., Forbes,M.S., & Herman,M.M. (2001) Aluminium and neuronal cell injury: Inter-relationships between neurofilamentous arrays and apoptosis. Journal of Inorganic Biochemistry 87, 15-19.

18.   Ghribi,O., Herman,M.M., Forbes,M.S., DeWitt,D.A., & Savory,J. (2001) GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-X L and inhibiting mitochondrial Bax translocation. Neurobiology of Disease 8, 764-773.

19.   Ghribi,O., Herman,M.M., DeWitt,D.A., Forbes,M.S., & Savory,J. (2001) A+¦(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-+¦B. Molecular Brain Research 96, 30-38.

20.   Cyr,M., Ghribi,O., Thibault,C., Morissette,M., Landry,M., & Di Paolo,T. (2001) Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors. Brain Research Reviews 37, 153-161.

21.   Calon,F., Morissette,M., Ghribi,O., Goulet,M., Grondin,R., Blanchet,P.J., B+¬dard,P.J., & DiPaolo,T. (2002) Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry 26, 127-138.

22.   Forbes,M.S., Ghribi,O., Herman,M.M., & Savory,J. (2002) Aluminum-induced dendritic pathology revisited: Cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons. Annals of Clinical and Laboratory Science 32, 75-86.

23.   Ghribi,O., Herman,M.M., & Savory,J. (2002) The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus. Neuroscience Letters 324, 217-221.

24.   Ghribi,O., Herman,M.M., Spaulding,N.K., & Savory,J. (2002) Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation. Journal of Neurochemistry 82, 137-145.

25.   Savory,J., Ghribi,O., & Herman,M.M. (2002) Is amyloid +¦-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions? Neurobiology of Aging 23, 1089-1092.

26.   Ghribi,O., Herman,M.M., & Savory,J. (2003) Lithium inhibits A+¦-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation. Journal of Neuroscience Research 71, 853-862.

27.   Savory,J., Herman,M.M., & Ghribi,O. (2003) Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain. Journal of Inorganic Biochemistry 97, 151-154.

28.   Ghribi,O., Herman,M.M., Pramoonjago,P., & Savory,J. (2003) MPP + Induces the Endoplasmic Reticulum Stress Response in Rabbit Brain Involving Activation of the ATF-6 and NF-KB Signaling Pathways. Journal of Neuropathology and Experimental Neurology  62, 1144-1153.

29.   Ghribi,O., Prammonjago,P., Herman,M.M., Spaulding,N.K., & Savory,J. (2003) A+¦(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. Molecular Brain Research 119, 201-206.

30.   Ghribi,O., Herman,M.M., Pramoonjago,P., Spaulding,N.K., & Savory,J. (2004) GDNF regulates the A+¦-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases. Neurobiology of Disease 16, 417-427.

31.   Griffioen,K.J.S., Ghribi,O., Fox,N., Savory,J., & DeWitt,D.A. (2004) Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release. NeuroToxicology 25, 859-867.

32.   Ghribi,O. (2006) The role of the endoplasmic reticulum in the accumulation of +¦-amyloid peptide in Alzheimer's disease. Current Molecular Medicine 6, 119-133.

33.   DeWitt,D.A., Hurd,J.A., Fox,N., Townsend,B.E., Griffioen,K.J.S., Ghribi,O., & Savory,J. (2006) Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis. Journal of Alzheimer's Disease 9, 195-205.

34.   Ghribi,O., Larsen,B., Schrag,M., & Herman,M.M. (2006) High cholesterol content in neurons increases BACE, +¦-amyloid, and phosphorylated tau levels in rabbit hippocampus. Experimental Neurology 200, 460-467.

35.   Savory,J., Herman,M.M., & Ghribi,O. (2006) Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease? Journal of Alzheimer's Disease 10, 25-27.

36.   Ghribi,O., Golovko,M.Y., Larsen,B., Schrag,M., & Murphy,E.J. (2006) Deposition of iron and +¦-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. Journal of Neurochemistry 99, 438-449.

37.   Savory,J., Herman,M.M., & Ghribi,O. (2006) Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease. Journal of Alzheimer's Disease 10, 135-144.

38.   Ghribi,O. (2006) Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease. Journal of Alzheimer's Disease 10, 407-408.

39.   Savory,J. & Ghribi,O. (2007) Can studies of aluminum toxicity in vivo and in vitro provide relevant information on the pathogenesis and etiology of Alzheimer's disease? Journal of Alzheimer's Disease 11, 429-430.

40.   Chen,X., Ghribi,O., & Geiger,J.D. (2008) Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis. American Journal of Physiology - Regulatory Integrative and Comparative Physiology 294, R829-R835.

41.   Schrag,M., Sharma,S., Brown-Borg,H., & Ghribi,O. (2008) Hippocampus of Ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus 18, 239-244.

42.   Chen,X., Gawryluk,J.W., Wagener,J.F., Ghribi,O., & Geiger,J.D. (2008) Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. Journal of Neuroinflammation 5. Ref ID: 43

43.   Jaya Prasanthi,R.P., Schommer,E., Thomasson,S., Thompson,A., Feist,G., & Ghribi,O. (2008) Regulation of +¦-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mechanisms of Ageing and Development 129, 649-655.

44.   Rantham Prabhakara,J.P., Feist,G., Thomasson,S., Thompson,A., Schommer,E., & Ghribi,O. (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and +¦-synuclein in human neuroblastoma SH-SY5Y cells. Journal of Neurochemistry 107, 1722-1729.

45.   Ghribi,O. (2008) Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. Journal of Alzheimer's Disease 15, 673-684.

46.   Sharma,S., Prasanthi,R.P., Schommer,E., Feist,G., & Ghribi,O. (2008) Hypercholesterolemia-induced A+¦ accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiology of Disease 32, 426-432.

47.   Prasanthi,J.R.P., Huls,A., Thomasson,S., Thompson,A., Schommer,E., & Ghribi,O. (2009) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on +¦-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Molecular Neurodegeneration 4.

48.   Wu,M., Audet,A., Cusic,J., Seeger,D., Cochran,R., & Ghribi,O. (2009) Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits. Journal of Neurochemistry 111, 1011-1021.

49.   Marwarha,G., Dasari,B., Prasanthi,J.R.P., Schommer,J., & Ghribi,O. (2010) Leptin reduces the accumulation of A+¦ and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. Journal of Alzheimer's Disease 19, 1007-1019.

50.   Chen,X., Ghribi,O., & Geiger,J.D. (2010) Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. Journal of Alzheimer's Disease 20, S127-S141.

51.   Dasari,B., Prasanthi,J.R., Marwarha,G., Singh,B.B., & Ghribi,O. (2010) The oxysterol 27-hydroxycholesterol increases +¦-amyloid and oxidative stress in retinal pigment epithelial cells. BMC Ophthalmology 10.

52.   Marwarha,G., Dasari,B., Prabhakara,J.P.R., Schommer,J., & Ghribi,O. (2010) +¦-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. Journal of Neurochemistry 115, 373-384.

53.   Prasanthi,J.R.P., Dasari,B., Marwarha,G., Larson,T., Chen,X., Geiger,J.D., & Ghribi,O. (2010) Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radical Biology and Medicine 49, 1212-1220.

54.   Chen,X., Wagener,J.F., Morgan,D.H., Hui,L., Ghribi,O., & Geiger,J.D. (2010) Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet. Journal of Alzheimer's Disease 22, 1289-1303.

55.   Marwarha,G., Prasanthi,J.R., Schommer,J., Dasari,B., & Ghribi,O. (2011) Molecular interplay between leptin, insulin-like growth factor-1, and +¦-amyloid in organotypic slices from rabbit hippocampus. Molecular Neurodegeneration 6.

56.   Dasari,B., Prasanthi,J.R., Marwarha,G., Singh,B.B., & Ghribi,O. (2011) Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. BMC Ophthalmology 11.

57.   Prasanthi,J.R.P., Larson,T., Schommer,J., & Ghribi,O. (2011) Silencing gadd153/chop gene expression protects against alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. PLoS ONE 6.

58.   Prasanthi, R. P. J., Marwarha, G., and Ghribi, O. The cholesterol-fed rabbit as a model system for cholesterol-Alzheimer's disease studies. 1, 163-178. 2011.

59.   Marwarha,G., Rhen,T., Schommer,T., & Ghribi,O. (2011) The oxysterol 27-hydroxycholesterol regulates +¦-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors-relevance to Parkinson's disease. Journal of Neurochemistry 119, 1119-1136.

60.   Marwarha,G. & Ghribi,O. (2012) Cellular model of Alzheimer's disease - Relevance to therapeutic testing. Experimental Neurology 233, 733-739.

61.   Marwarha,G., Dasari,B., & Ghribi,O. (2012) Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. Cellular Signalling 24, 484-492.

62.   Liu,R., Lei,J.X., Luo,C., Lan,X., Chi,L., Deng,P., Lei,S., Ghribi,O., & Liu,Q.Y. (2012) Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease. Neurobiology of Disease 45, 902-912.

63.   Prasanthi,J.R.P., Schrag,M., Dasari,B., Marwarha,G., Dickson,A., Kirsch,W.M., & Ghribi,O. (2012) Deferiprone reduces amyloid-+¦ and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. Journal of Alzheimer's Disease 30, 167-182.

64.   Zhang,H., Wang,Z., Stupak,J., Ghribi,O., Geiger,J.D., Liu,Q.Y., & Li,J. (2012) Targeted glycomics by selected reaction monitoring for highly sensitive glycan compositional analysis. Proteomics 12, 2510-2522.

  1. Mital Y. Patel, Hirenkumar V. Panchal, Othman Ghribi, and Kenza E. Benzeroual. (2012) The neuroprotective effect of fisetin in the MPTP model of Parkinson’s disease. Journal of Parkinson’s Disease 2: 287-302

66       Gurdeep Marwarha, Othman Ghribi (2012) Leptin signaling and Alzheimer’s disease. Am J Neurodegener Dis 1:245-265

67        Bhanu Dasari, Jaya RP Prasanthi, Craig Meiers, Brij B Singh, Othman Ghribi. (2013) Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. Current Eye Research 2013.

68       Gurdeep Marwarha, Shaneabbas Raza, Jaya R.P Prasanthi, and Othman Ghribi. (2013)Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. PLoS ONE 2013 Aug 9;8(8):e70773. doi: 10.1371/journal.pone.0070773.

69          Schrag M, Mueller C, Zabel M, Crofton A, Kirsch WM, Ghribi O, Squitti R, Perry G. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis. Neurobiol Dis. 2013 Jul 15. pii: S0969-9961(13)00199-X. doi: 10.1016/j.nbd.2013.07.005

70       Qing Yan Liu, Marilyn N. Vera Chang, Joy X Lei, Roger Koukiekolo, Brandon Smith, Dongling Zhang and Othman Ghribi (2014) Identification of microRNAs involved in Alzheimer’s progression using a rabbit model of the disease. Am J Neurodegener Dis. 2014 Mar 28;3(1):33-44.

71       Marwarha G, Raza S, Meiers C, Ghribi O. Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway. Biochim Biophys  Acta. 2014;1842(9):1587-95

72       Danielle Morgan, Othman Ghribi, Liang Hui, Jonathan D. Geiger, and Xuesong Chen. Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits.  American Journal of Physiology - Endocrinology and Metabolism 2014;307(12):E1125-30

73       Kate J. Claycombe, Catherine Brissette, and Othman Ghribi. Epigenetics of inflammation, maternal infection, and nutrition. J Nutr. 2015 May;145(5):1109S-15S

74       Kate J. Claycombe, Emilie E. Vomhof-DeKrey,  James N. Roemmich, Amy Bundy,  Turk Rhen, and Othman Ghribi. Maternal low protein diet causes body weight loss in male, neonate Sprague-1 Dawley rats involving UCP-1 mediated thermogenesis. J Nutr Biochem. 2015 Jul;26 (7):729-35.

75       Marwarha G, Ghribi O. Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? Exp Gerontol. 2015 Aug; 68:13-8.

76       Shaneabbas Raza, Joyce E Ohm, Archana Dhasarathy, Jared Schommer, Conor Roche, Kimberly DP Hammer, and Othman Ghribi.. The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. Molecular and Cellular Biochemistry 2015 Dec;410(1-2):187-95

77       Gurdeep Marwarha and Othman Ghribi. NF-κB – a friend, a foe, or a bystander - in the neurodegenerative cascade and pathogenesis of Alzheimer’s disease. Invited Review; in revision, CNS & Neurological Disorders - Drug Targets

78       Shaneabbas Raza, Megan Meyer, Jared Schommer, Kimberly DP Hammer, Bin Guo and Othman Ghribi. 27-hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. Medical Oncology, 2016 Feb;33(2):12. doi: 10.1007/s12032-015-0725-5

79       Qing Yan Liu, Roger Koukiekolo, Dongling Zhang, Brandon Smith, Dao Ly, Joy X Lei, and Othman Ghribi. Molecular events linking cholesterol to Alzheimer’s disease and inclusion body myositis in a rabbit model. Am J Neurodegener Dis 2016;5(1):74-84

80       Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly DP Hammer, Bin Guo and Othman Ghribi. The cholesterol metabolite, 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells. (In revision)

81       Shaneabbas Raza and Othman Ghribi. 27-hydroxycholesterol: A new player in hormonal cancers. The Journal of Steroid Biochemistry and Molecular Biology (in revision)

82       Emilie Vomhof-DeKrey Diane Darland, Othman Ghribi, Amy Bundy, James Roemmich, Kate Claycombe. Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFα expression in Sprague-Dawley rats. Journal of Reproductive Immunology (in press)

83       Chen X, Wagener JF, Ghribi O, Geiger JD. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016 Jun 8;8:129. doi: 10.3389/fnagi.2016.00129.

84       Gurdeep Marwarha, Kate Claycomb, Jared Schommer, David Collins, and Othman Ghribi. Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like Growth Factor 1 expression in the brain. Cell Signal. 2016 Aug 20;28 (11):1789-1805.

 

  1. Invited oral presentations
  2. Palmitate-induced ER Stress and Subsequent CHOP Activation Attenuates Leptin and IGF1              Expression – Implications for Alzheimer’s Disease, 2nd Neurological Disorders Summit. September                 07-09, 2016 DoubleTree By Hilton, Baltimore, MD, USA
  3. Regulation of α-synuclein levels by 27-hydroxycholesterol-Relevance to Synucleinopathies.           Current Trends in Oxysterols and related sterols: Biological and Medical aspects, The European Network for Oxysterol Research. September 29-30, Paris Descartes.

 

  1. The cholesterol oxidation products may underlie α-synuclein accumulation in Alzheimer’s disease and Parkinson’s disease. Controversy in Neurology, Lisbon, Portugal March 17-22, 2016
  2. The Multi-Faceted Actions of the Cholesterol Oxidation Products in Health and Disease. 103rd Indian Science Congress, Mysore University, India January 2016.
  3. Oxysterols and Neurodegenerative diseases. International Conference on Neurology and Epidemiology, 5th Scientific meeting, Gold Coast, Australia, November 2015
  4. Oxysterols-Multifaceted players in neurodegenerative disease. Neurological Disorders Summit; San Francisco, July 06-08, 2015
  5. Oxysterols in Alzheimer’s disease. Abbott/Abbvie laboratories, Chicago, IL.  October 29th, 2014
  6. Does the oxysterol 27-hgydroxycholesterol underlie Alzheimer’s disease/Parkinson’s disease overlap? The 12th International symposium on neurobiology and neuroendocrinology of aging, Bregenz, Austria, July 2014.
  7. The role of the oxysterol 27-hydroxycholesterol in Alzheimer’s disease-like pathology. Loma Linda University, January 30th, 2014 (Host: Dr. Soriano).
  8. The multifaceted roles of the oxysterol 27-hydroxycholesterol. West Virginia University at Morgantown, December 3, 2013 (Host: Dr. Schreurs).
  9. Saturated free fatty acid consumption may increase the risk for Alzheimer’s disease. Nanosymposium on Alzheimer’s disease and inflammation, Neuroscience meeting, October 2012, New Orleans.
  10. Alzheimer’s disease and Parkinson’s disease overlap-A role for Oxysterols? International Conference and Exhibition on Neurology & Therapeutics-Novel Therapies in Neurosciences, May 14, 2012. Las Vegas, NV.
  11. Cholesterol and Age-Related Macular Degeneration. Loma Linda School of Medicine, June 2, 2011 (Host Dr. Kirsch).
  12. Regulation of Tyrosine hydroxylase and α-synuclein levels by LXR and estrogen receptors-relevance to Parkinson’s disease. The 10th Annual International Conference AD/PD, Barcelona, Spain, March 9-13, 2011.
  13. Cholesterol and Alzheimer’s disease-Is there a connection? The Alzheimer's Association Minnesota-North Dakota Chapter. Minneapolis, March 19, 2011.
  14. Cholesterol and Alzheimer’s disease. Annual conference sponsored by St. Alexius, the ND Hospice Organization, and the Alzheimer's Association Minnesota-North Dakota. Bismarck, ND October 16, 2009.
  15. Common pathological hallmarks for Alzheimer’s disease and age-related macular degeneration in the cholesterol-fed rabbit model. Department of Anatomy, University of North Dakota School of Medicine. November 2, 2009
  16. Oxysterols alter expression levels of tyrosine hydroxylase, alpha-synuclein, and beta-amyloid: relevance to Parkinson’s and Alzheimers’s diseases. The 9th Annual International Conference AD/PD, Prague, Czech Republic, March 11-15, 2009.
  17. Cholesterol-Induced Alzheimer’s Disease-like pathology in rabbit brain. Loma Linda University, School of Medicine, January 4th 2008.
  18. Alzheimer’s disease: social impact and care givers role. Department of Sociology, University of North Dakota, February 7th 2008.
  19. Nutrition and neurodegenerative disorders. University Senghor, Alexandria, Egypt, February 2008.
  20. Alzheimer Disease: a cause of pathological aging. Department of Sociology, University of North Dakota, February 9, 2006
  21. Cholesterol-Induced Oxidative Stress & the Pathogenesis of Alzheimer’s Disease. Department of Anatomy, University of North Dakota School of Medicine. November 21st, 2005.
  22. Neurotoxic Injury: Regulation by Mitochondrial-Endoplasmic Reticulum Cross-talk. University of Quebec at Trois-Rivieres, March 2004.
  23. Ab(1-42)-induced phosphorylation of tau and apoptosis in an in vivo model: mechanisms and pathways. St Elizabeth Medical Center, Boston, MA, January 7, 2004.
  24. Mechanisms of Neuronal Death in Experimental Degeneration, DRDC Suffield, Alberta, Canada, June 2003.
  25. Lithium inhibits Aß-induced caspase-3 activation, GSK-3 AND JNK phosphorylation, but not oxidative stress, in rabbit brain hippocampus. The 8th international conference on Alzheimer’s disease and related disorders. Stockholm, Sweden, July 20-25, 2002. Neurobiology of aging 23 (1): 510 Suppl. 1 JUL-AUG 2002
  26. Mitochondrial injury and apoptosis in Aluminum-induced neurotoxicity. Robert O. Lawson Chair in Neural Repair and Regeneration, Head Spinal Program, Toronto Western Hospital, University Health Network, January 8, 2001.
  27. Changes in protein-regulating apoptosis in an experimental model of neurodegeneration: Institute of Biological Sciences, NRC, Ottawa, Canada, February 2, 2001
  28. Local NMDA receptor blockade decreases extracellular glutamate and aspartate levels during forebrain ischaemia in rat striatum. 50th meeting of l'Association Française des Pharmacologistes. Lille, October 6-9, 1993. Fund. Clin. Pharmacol, 7:360, 1993.
  29. Les antagonistes des récepteurs NMDA réduisent l'accumulation des acides aminés excitateurs induite par une ischémie cérébrale chez le rat. Circulation et Métabolisme du Cerveau, 10:168-176 1993.
  30. Kynurenic acid but not MK-801 reduces the extracellular amino acid accumulation in rat striatum and hippocampus during cerebral ischaemia. 48th Meeting of l'Association Française des Pharmacologistes. Montpelier, October 1-2, 1992. Fund. Clin. Pharmacol. 6:393, 1992.

Certifications:

Certificate in Pharmacokinetic and Drug Monitoring, St-Antoine School of Medicine, Paris, France 1989

Certificate in Pharmacology of Psychotropic Drugs, Pitié-Salpêtrière Hospital, Paris, France, 1988

Certificate in Clinical Trial Management, Saint-Antoine School of Medicine, Paris France 1988

Awards:

2010; 2012; 2014      Outstanding Block (III and IV) Instructor Award for medical student teaching

2010:                           Dean David Wilson Academic Award in Neuroscience

2009:                          North Dakota Spirit Faculty Achievement Award

2007:                          University of North Dakota Faculty Star

2002:                          Alzheimer's & Related Diseases Research Award, Virginia Center On Aging

1997:                          Alzheimer’s Society of Canada postdoctoral grant (1997 -1999).
1994:                          Laureate of Pharmaceutical and Biological Sciences School, René Descartes University, Paris, France.

1994:                          Roussel Laboratories (France) First price Award for Thesis Dissertation.

PhD in Experimental and Clinical Pharmacology, Renes Descartes University, Paris-France

Master's in Experimental and Clinical Pharmacology, Saint-Antoine School of Medicine, Pierre et Marie Curie University, Paris, 1990

Bachelor in Biological and Medical Sciences in Pharmacology, School of Medicine Lariboisière Saint-Louis, Paris, 1988.

2016-present: Professor, Department of Biomedical Sciences, University of North Dakota School of Medicine

2010-2016: Associate Professor, Department of Pharmacology, Physiology and     

                           Therapeutics, and the Department of Basic Sciences, University of North Dakota School of Medicine.

2004-2010: Assistant Professor, Department of Pharmacology, Physiology and

                     Therapeutics, University of North Dakota School of Medicine.

2001-2004: Assistant Professor of Pathology (non-tenure track), University of Virginia Health             

                      System, Charlottesville, VA.

1999-2001: Research Associate, Department of Pathology, University of Virginia Health system

1996-1999: Postdoctoral Fellow, Department of Biochemistry, University of Quebec, Canada.

1994-1996: Clinical Pharmacologist: Pharmacokinetic and drug monitoring, Clinical Pharmacology

                     and Toxicology Unit, Ville-Evrard Hospital, Neuilly sur Marne, France.

1988-1994: Intern, Clinical Pharmacology Unit, Ville-Evrard Hospital, Neuilly sur Marne, France