Ramkumar Mathur

Aging, Cellular Senescence, IBD, Host-pathogen Interaction, Neurodegenrative diseases

1. Shilpi Jain1, Eden Abrham1, M. Nadeem Khan2, Ramkumar Mathur1,* (*Corresponding author). Aging and Disease. DOI: 10.14336/AD.2020.1019

2. Deficiency of microglial autophagy increases the density of oligodendrocytes and susceptibility to severe forms of seizures. Alam MM, Zhao XF, Liao Y, Mathur R, McCallum SE, Mazurkiewicz JE, Adamo MA, Feustel P, Belin S, Poitelon Y, Zhu XC, Huang Y.eNeuro. 2021 Jan 14:ENEURO.0183-20.2021. DOI: 10.1523/ENEURO.0183-20.2021. Online ahead of print.PMID: 33472865

3. Microglial mTOR is Neuronal Protective and Antiepileptogenic in the Pilocarpine Model of Temporal Lobe Epilepsy. Zhao XF, Liao Y, Alam MM, Mathur R, Feustel P, Mazurkiewicz JE, Adamo MA, Zhu XC, Huang Y.J Neurosci. 2020 Sep 30;40(40):7593-7608. doi: 10.1523/JNEUROSCI.2754-19.2020. Epub 2020 Aug 31.PMID: 32868461
4. IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis. Schmit T, Ghosh S, Mathur RK, Barnhardt T, Ambigapathy G, Wu M, Combs C, Khan MN.J Immunol. 2020 Jul 15;205(2):469-479. DOI: 10.4049/jimmunol.1900755. Epub 2020 Jun 15.PMID: 32540994
5. Editorial: Cross-Talk Between Inflammation and Barrier Framework at Mucosal Surfaces in the Lung: Implications for Infections and Pathology. Mathur R, Murugaiyan G, Khan MN.Front Immunol. 2020 Sep 29;11:598533. DOI: 10.3389/fimmu.2020.598533. PMID: 33133108 
6. Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin. R Mathur*.  JoVE (Journal of Visualized Experiments), e6006, 2019. PMID 31566603  * Corresponding author
7. Targeting microglia using Cx3cr1-cre lines: revisiting the specificity. XF Zhao, MM Alam, Y Liao, T Huang, R Mathur, X Zhu, Y Huang. eNeuro 6 (4, 2019. PMID 31201215
8. Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis. R Mathur* et al. Mucosal immunology 12 (3), 612, 2019. PMID 30765845  * Corresponding author.   
9. Double-Edged Role of Interleukin 17A in Streptococcus pneumoniae Pathogenesis During Influenza Virus Coinfection.Ganesh Ambigapathy, Taylor Schmit, Ram Kumar Mathur, Suba Nookala, Saad Bahri, Liise-anne Pirofski, M Nadeem Khan. The Journal of infectious diseases, 220 (5), 902-912 2019, 2019. PMID 31185076
10. Noninflammatory changes of microglia are sufficient to cause epilepsy. Xiaofeng Zhao, Yuan Liao, Shannon Morgan, Ramkumar Mathur, Paul Feustel, Joseph Mazurkiewicz, Jiang Qian, Julia Chang, Gary W Mathern, Matthew A Adamo, Anthony L Ritaccio, Michael Gruenthal, Xinjun Zhu, Yunfei Huang. Cell reports 22 (8), 2080-2093, 2018. PMID 29466735 
11. MTOR-MEDIATED SUPPRESSION OF AUTOPHAGY ACTIVITY IN CX3CR1+ MONONUCLEAR PHAGOCYTES CONTRIBUTES TO INTESTINAL FIBROSIS.Ramkumar Mathur,Yunfei Huang, Xinjun Cindy Zhu. Gastroenterology, 2018, Volume 154, Issue 1, Supplement, Pages S39–S40. DOI: 10.1053/j.gastro.2017.11.118
12. Attenuation of in vitro host–pathogen interactions in quinolone-resistant Salmonella Typhi mutants. Clara Ballesté-Delpierre, Anna Fabrega, Mario Ferrer-Navarro, Ramkumar Mathur, Sankar Ghosh, Jordi Vila. Journal of Antimicrobial Chemotherapy 71 (1), 111-122, 2016. PMID 26446080
13. SHP-1 plays a crucial role in CD40 signaling reciprocity. Tabish Hasan Khan, Neetu Srivastava, Ankita Srivastava, Archana Sareen, Ram K Mathur, Ajit G Chande, Krishnasastry V Musti, Somenath Roy, Robin Mukhopadhyaya, Bhaskar Saha. The Journal of Immunology 193 (7), 3644-3653, 2014. PMID: 25187664
14. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. A Alicia Koblansky, Dragana Jankovic, Hyunju Oh, Sara Hieny, Waradon Sungnak, Ramkumar Mathur, Matthew S Hayden, Shizuo Akira, Alan Sher, Sankar Ghosh.Immunity 38 (1), 119-130, 2013. PMID 23246311
15. A mouse model of Salmonella typhi infection. Ramkumar Mathur, Hyunju Oh, Dekai Zhang, Sung-Gyoo Park, Jin Seo, Alicia Koblansky, Matthew S Hayden, Sankar Ghosh. Cell 151 (3), 590-602, 2012. PMID 23101627
16. T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Sung-Gyoo Park, Ramkumar Mathur, Meixiao Long, Namiko Hosh, Liming Hao, Matthew S Hayden, Sankar Ghosh. Immunity 33 (5), 791-803, 2010. PMID 21074460
17. An unusual pro-inflammatory role of interleukin-10 induced by arabinosylated lipoarabinomannan in murine peritoneal macrophages.Nivedita Majumder, Ranadhir Dey, Ram Kumar Mathur, Sriparna Datta, Madhumita Maitra, Sanjukta Ghosh, Bhaskar Saha, Subrata Majumdar. Glycoconjugate journal 23 (9), 675-686, 2006. PMID 17115274
18. The conundrum of CD40 function: host protection or disease promotion? Ram K Mathur, Amit Awasthi, Bhaskar Saha. Trends Parasitology, 22 (3), 117-22, Mar 2006. PMID: 16446115
19. Immune response to Leishmania infection. A Awasthi, RK Mathur, B Saha. Indian Journal of Medical Research, 119 (6), 238-58 Jun 2004. PMID: 15243162
20. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Ram Kumar Mathur, Amit Awasthi, Pallavi Wadhone, Boppana Ramanamurthy, Bhaskar Saha. Nature medicine 10 (5), 540, 2004. PMID 15107845
21. CD40 signaling is impaired in L. major–infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. Amit Awasthi, Ramkumar Mathur, Aslam Khan, Bimba N Joshi, Nitya Jain, Sangeeta Sawant, Ramanamurthy Boppana, Debashis Mitra, Bhaskar Saha. Journal of Experimental Medicine. 197 (8), 1037-1043, 2003. PMID 12695487 

Crohn's And Colitis Foundation of America, 2016-2019 

Ph.D.                                      National Center for Cell Science, Pune University, Pune, India

Postdoc                                  Yale University, New Haven, Connecticut, USA

Associate Research Scientist    Columbia University, New York, USA