Determining the pathways and mechanisms that hormones utilize may suggest potential therapeutic interventions that could lead to strategies to delay aging, treat aging-related disorders and extend life span in humans.The somatotropic axis plays a major role in aging and longevity. Mice with hereditary dwarfism (Ames dwarf, df/df) and growth hormone (GH) deficiency exhibit delayed aging, living 49-68% longer (males and females, respectively) than normal siblings and differences in their antioxidant defense capacity, mitochondrial function, metabolism, stress resistance and DNA methylation patterns. In contrast, mice with high plasma GH concentrations live half as long as normal, wild type siblings and exhibit depressed antioxidative defense capacity and reduced stress resistance. The overall hypothesis is that reduced somatotropic signaling confers a biologic advantage (increased healthspan and delayed aging) to mammals with better enzymatic scavenging of toxic metabolic byproducts, less mitochondrial membrane leakage, and enhanced stress resistance. Our current studies are designed to further understand the relationship between cellular metabolism, hormones, mitochondrial activities and aging in various mouse strains of extended and shortened life spans. The epigenetic signature of long-living mice also differs from normal animals in terms of DNA methylation patterns and the underlying mechanisms that promote methylation. We are investigating the interplay between hormone levels, methylation and gene expression in terms of aging and age-related disease.
JOURNAL ARTICLES
Brown-Borg HM. 2022. Growth hromone, not IGF-1 is the key longevity regulator in mammals. J Gerontol A Biol Sci Med Sci. Apr 18:glac092. doi: 10.1093/gerona/glac092
Perazza L, Brown-Borg HM, Thompson LV. 2022. Physiological systems promoting frailty. Comprehensive Physiology. (in press).
Bartke A, Brown-Borg H. 2021. Mutations affecting mammalian aging: GH and GHR vs IGF-1 and insulin. Front Genet. 2021 Nov 24;12:667355. doi: 10.3389/fgene.2021.667355
Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg HM, Jurivich D. 2021. Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice. Geroscience 43(4):1921-1934. doi: 10.1007/s11357-021-00362-w.
Zhu R, Yan, T, Feng Y, Liu Y, Cao H, Peng G, Yang Y, Xu Z, Liu J, Hou W, Wang X, Li Z, Deng L, Wang S, Li J, Han Q, Li H, Shan G, Cao Y, An X, Yan J, Zhang Z, Li H, Qu X, Zhu J, Zhou S, Wang J, Zhang F, Gao J, Jin R, Xu D, Ma Y, Huang T, Peng S, Zheng Z, Stambler I, Gilson E, Lim LW, Moskalev A, Cano A, Chakrabarti S, Ulfhake B, Su H, Xu H, Xu S, Wei F, Brown-Borg HM, Min K-J, Ellison-Hughes G, Caruso C, Jin K, Zhao RC. 2021. Mesenchymal stem cell treatment improves outcomes in COVID-19 patients via multiple immunomodulatory mechanisms. Cell Research-Nature 26:1-19. doi: 10.1038/s41422-021-00573-y.
Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Bene M, Johnson FB, Brown-Borg H, Nogouchi E, Sell C. 2022. The methyltransferase enzymes, KMT2D, SETD1B, and ASH1L, are key mediators of both metabolic and epigenetic changes during cellular senescence. Molecular Biology of the Cell May 1;33(5):ar36. doi: 10.1091/mbc.E20-08-0523.
Pabis K, Chiari Y, Sala C, Straka E, Giacconi R, Provinciali M, Brown-Borg H, Nowikovsky K, Valencak T, Gundacker C, Garagnani P, Malavolta M. 2021. Elevated metallothionein in long-lived species mediates the influence of cadmium accumulation on aging. Geroscience 43(4):1975-1993. doi:10.1007/s11357-021-00393-3.
Tomkinson GR, Kidokoro T, Dufner T, Noi S, Fitzgerald JS, Brown-Borg HM. 2021. Temporal trends in the 6-minute walking distance of older Japanese adults between 1998 and 2017. Journal of Sport and Health Science 10(4):462-469. doi: 10.1016/j.jshs.2020.06.007.
Thelen, M, Brown-Borg, HM. 2020. Does diet have a role in the treatment of Alzheimer’s disease? Frontiers in Aging Neuroscience. 12:617071. doi: 10.3389/fnagi.2020.627071.
Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg HM, Jurivich D. 2021. Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice. Geroscience doi: 10.1007/s11357-021-00362-w.
Brown-Borg HM. 2020. ‘A glance back’ at the Journals of Gerontology: We’ve come a long way, baby! J Gerontol A Biol Sci Med Sci 75(2):205-206.
Brown-Borg HM, Borg KE. 2020. A summary of the Proceedings of the Fourteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 15-20, 2018. Geroscience 42(5):1195-1198. doi: 10.1007/s11357-020-00234-9.
Tomkinson GR, Kidokoro T, Dufner T, Noi S, Fitzgerald JS, Brown-Borg HM. 2020. Temporal trends in the 6-minute walking distance of older Japanese adults between 1998 and 2017. Journal of Sport and Health Science S2095-2546(20)30073-9. doi: 10.1016/j.jshs.2020.06.007.
Buffenstein R, Lewis KN, Gibney PA, Grimes K, Narayan V, Smith M, Lin T, Brown-Borg HM. 2020. Probing paedomorphy and prolonged lifespan in the naked mole-rats and dwarf mice. Physiology 35(2): 96-111. doi.org/10.1152/physiol.00032.2019
Jurivich D, Manocha G, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H. 2020. Multi-factorial attenuation of the murine heat shock response with age. J Gerontol A Biol Sci doi: 10.1093/gerona/glz204.
Royce GH, Brown-Borg HM, Deepa SS. 2019. The potential role of necroptosis in inflammaging and aging. Geroscience 41(6):795-811. Doi:10.1007/s11357-019-00131-w.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Borg KE, Rojanathammanee L. 2018. Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation. Annals of the New York Academy Sciences 1418(1):118-136.
Brown-Borg HM. Disentangling high fat, low carb and healthy aging. 2017. Cell Metabolism 26(3):458-459.
Brown-Borg HM, Anderson RM. 2017. Metabolic adventures in aging research. Molecular and Cellular Endocrinology 455 (1-3).
Cole JJ, Robertson NA, Rather MI, McBryan T, Brock C, Clark W, Miller RA, Brown-Borg H*, Adams PD*. 2017. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biology 18(1):58. *Corresponding authors
Wang T, Tsui B, Kreisberg JF, Robertson NA, Gross AM, Carter H, Brown-Borg H, Adams PD, Ideker T. 2017. Epigenetic aging signatures in mice is slowed by dwarfism, caloric restriction and Rapamycin treatment. Genome Biology 18(1):57.
Brown-Borg HM, Borg KE. 2017. A summary of the Proceedings of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17-22, 2016. Experimental Gerontology 94:1-128..
Brown-Borg HM, Buffenstein R. 2016. Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan? Ageing Research Reviews pii: S1568-1637(16)30204-5. doi: 10.1016/j.arr.2016.08.007.
Puig KL, Kulas JA, Franklin W, Rakoczy SG, Taglialatela G, Brown-Borg HM, Combs CK. 2016. The Ames dwarf mutation attenuates Alzheimer’s disease phenotype of APP/PS1 mice. Neurobiology of Aging 40:22-40. doi: 10.1016/j.neurobiolaging.2015.12.021.
Brown-Borg HM. 2015. Reduced GH signaling and methionine restriction: Interventions that improve metabolic health and lifespan. Annals of the New York Academy of Sciences. 1363(1):40-49.
Brown-Borg HM. 2015. The somatotropic axis and longevity in mice. Am J Physiology Endo Metab. 309(6):E503-510. doi:10.1152/ajpendo.00262.2015.
Brown-Borg, HM, Borg KE. 2015. A summary of the proceedings of the Twelfth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 27-August 1, 2014. Experimental Gerontology doi:10.1016/j.exger.2015.01.004.
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y,Vijg J, Vinciguerra M, Fontana L. 2015. Interventions to slow aging in humans: Are we ready? Aging Cell 14(4):497-510. doi: 10.1111/acel.12338
Brown-Borg HM, S Rakoczy, JA Wonderlich, V Armstrong, L. Rojanathammanee. 2014. Altered dietary methionine differentially impacts glutathione and methionine metabolism in long living growth hormone deficient Ames dwarf and wild type mice. Longevity and Healthspan 3:10. doi:10.1186/2046-2395-3-10.
Brown-Borg, H.M., S. Rakoczy, J.A. Wonderlich, L. Rojanathammanee, J.J. Kopchick, V. Armstrong and D. Raasakka. 2014 Growth hormone signaling is necessary for lifespan extension by dietary methionine. Aging Cell 13(6):1019-1027. doi: 10.1111/acel.12269.
Rojanathammanee, L., S. Rakoczy, J.J. Kopchick and H.M. Brown-Borg. 2014. Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice. AGE 36(4):9687-9693. doi: 10.1007/s11357-014-9687-3
Ables, G.P., H.M. Brown-Borg, R. Buffenstein, C.D. Church, A.K. Elshorbagy, V.D. Gladyshev, T. Huang, R.A. Miller, J.R. Mitchell, J.P. Richie, B. Rogina, M.H. Stipanuk, D.S. Orentreich, and N. Orentreich, 2014. The first international mini-symposium on methionine-restriction and lifespan. Frontiers in Genetics: Genetics of Aging 5:122. 09 May/doi: 10.3389/fgene.2014.00122.
Derenne, A., H.M. Brown-Borg, S. Martner, W. Wolff, M. Frerking. 2014. Spatial delayed nonmatching-to-sample performances in long-living Ames dwarf mice. Physiology and Behavior 123:100-104. PMID 24140989
Rojanathammanee, L., S. Rakoczy and H.M. Brown-Borg. 2014. Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 69(10):1199-1211. doi: 10.1093/gerona/glt178
Armstrong, V.L., S. Rakoczy, L. Rojanathamannee, H.M. Brown-Borg. 2014. Expression of DNA methyltransferases are influenced by growth hormone in the long living Ames dwarf mouse. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 69(8): 923-933. doi:10.1093/gerona/glt133
Romanick, M.A., L.V. Thompson and H.M. Brown-Borg. 2013. Murine models of atrophy, cachexia and sarcopenia in skeletal muscle. Biochimica et Biophysica Acta. 1832:1410-1420. doi:10.1016/j.bbadis.2013.03.011
Brown-Borg, H.M. and K.E. Borg. 2013. A summary of the proceedings of the Eleventh International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 29-August 3, 2012. Experimental Gerontology 48(7):593-595.
Brown-Borg, H.M., and S. Rakoczy. 2013. Metabolic adaptations to short-term every other day feeding in long-living Ames dwarf mice. Experimental Gerontology 48:905-919. doi.org/10.1016/j.exger.2013.06.009
Brown-Borg, H.M. and A. Bartke. 2012. GH and IGF1: Roles in energy metabolism of long-living GH mutant mice. J. Gerontology Series A: Biological Sciences and Medical Sciences 67(6):652-660 doi: 10.1093/Gerona/gls086. PMC3348496
Anisimov, V.N., Bartke, A., Barzilai, N., Batin, M.A., Blagosklonny, M.V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., Franceschi, C., Gems, D., Gladyshev, V., Gorbunova, V., Gudkov, A.V., Kennedy, B., Konovalenko, M., Kraemer, B., Moskalev, A., Petropoulos, I., Pasyukova, E., Rattan, S., Rogina, B., Seluanov, A., Shaposhnikov, M., Shmookler Reis, R., Tavernarakis, N., Vijg, J., Yashin, A., Zimniak, P. 2012. The second international conference on ‘genetics of aging and longevity’. Aging 4(5):305-317.
Traustadottir, T., S.S. Davies, Y. Su, L, Choi, H.M. Brown-Borg, L.J. Roberts, II, and S.M. Harman. 2012. Oxidative stress in older adults: Effects of physical fitness. AGE 34:969-982. doi:10.1007/s11357-011-9277-6.
Brown-Borg, H.M., W.T. Johnson and S. Rakoczy. 2012. Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice. AGE 34(1):43-57. doi:10.1007/s11357-011-9212-x. PMID 3260352
Morrissey, M.B., H.M. Brown-Borg, R. de Cabo and M. Silverstein. 2011. An interdisciplinary look at advancing pain care, education and research: Responding to the IOM’s call to action to improve pain management. From Publication to Practice – The Gerontological Society of America pp. 1-4.
Sharma, S., D. Darland, S. Lei, S. Rakoczy and H.M. Brown-Borg. 2011. NMDA and kainate receptor expression, long-term potentiation and neurogenesis in long-lived Ames dwarf mice. AGE 34(3):609-620 doi:10.1007/s11357-011-9253-1. PMC3337943
Brown-Borg, H.M. and K.E. Borg. 2011. A summary of the proceedings of the Tenth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 25-30, 2010. Experimental Gerontology Vol. 46 Issues 2-3. PMC3159923
Derenne, A., H.M. Brown-Borg, K. Feltman, G. Corbett and S. Lackman. 2011. Acquisition of steady-state operant behavior in long-living Ames dwarf mice. Physiology and Behavior 104(5):1048-1052. doi:10.1016/j.physbeh.2011.07.006
Sharma, S., J. Haselton, S.G. Rakoczy, S. Branshaw, and H.M. Brown-Borg. 2010. Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neuronal loss. Mechanisms of Ageing & Development 131(6):422-435 doi:10.1016/j.mad.2010.06.004
Sharma, S., S.G. Rakoczy and H.M. Brown-Borg. 2010. Assessment of spatial memory in mice. Life Sciences 87(17-18):521-536. doi:10.1016/j.lfs.2010.09.004
Sharma, S., S.G. Rakoczy, K. Dahlheimer and H.M. Brown-Borg. 2010. The hippocampus of Ames dwarf mice is resistant to kainic acid-induced oxidative stress. Experimental Gerontology 45:936-949.
Vallanat, B., S.P. Anderson, H.M. Brown-Borg, H. Ren, S. Jonnalagadda, R. Srinivasan and J.C. Corton. 2010. Analysis of the heat shock response in the mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor a (PPARa). BMC Genomics 11:16-24. PMC2823686
Ren, H., Vallanat, B., H.M. Brown-Borg, R. Currie, and J.C. Corton. 2010. Regulation of proteome maintenance gene expression by activators of peroxisome proliferator-activated receptor a. PPAR Research 2010; 2010:727194. doi10.1155/2010/727194 PMC3026993
Chen, C-n, H.M. Brown-Borg, S. Rakoczy, D. Ferrington, L.V. Thompson. 2010. Aging impairs the expression of glutamate cysteine ligase catalytic subunit in soleus muscle under stress. J. Gerontology: Biological Sciences 65(2):129-137. doi: 10.1093/gerona/glp194. PMC2806238
Brown-Borg, H.M. 2009. Hormonal control of aging in rodents: The somatotropic axis. Molecular and Cellular Endocrinology 299(1):64-71.
Brown-Borg, H.M., S. G. Rakoczy, S. Sharma and A. Bartke. 2009. Long-living growth hormone receptor knock out mice: potential mechanisms of altered stress resistance. Experimental Gerontology 44:10-19. PMC2743895
Dhanasekaran, M., S.S. Karuppagounder, S. Uthayathas, L. Wold, K. Parameshwaran, J. Babu, V. Suppiramaniam and H. Brown-Borg. 2008. Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content. Life Sciences 83:92-95.
Chen, C.-n., H.M. Brown-Borg, S.G. Rakoczy, L.V. Thompson. 2008. Muscle disuse: adaptation of antioxidant systems is age-dependent. J Gerontology: Biological Sciences 63A(5):461-466. PMC2670877
Shavali, S., H.M. Brown-Borg, M. Ebadi and J. Porter. 2008. Mitochondrial localization of alpha-synuclein protein in alpha-synuclein-overexpressing cells. Neuroscience Letters 439(2):125-128. PMC2502066
Dhanasekaran, M., C.B. Albano, L. Pellet, S.S. Karuppagounder, S. Uthayathas, V. Suppiramaniam, H.M. Brown-Borg, M. Ebadi. 2008. Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced toxicity. Neurochemical Research 33(6):980-984 .
Schrag, M., S. Sharma, H.M. Brown-Borg and O. Ghribi. 2008. Hippocampus of Ames dwarf mice is resistant to b-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus 18(3):239-244.
Brown-Borg, H.M. 2007. Hormonal regulation of longevity in mammals. Ageing Research Reviews 6:28-45. PMC1978093
Brown-Borg, H.M. 2006. Longevity in mice: Is stress resistance a common factor? AGE 28:145-162. PMC2464727
Uthus, E.O., and H.M. Brown-Borg. 2006. Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse. Mechanisms of Ageing & Development 127:444-450. PMC2014095
Dhanasekaran, M., S. Uthayathas, S.S. Karuppagounder, K. Parameshwaran, V. Suppiramaniam, M. Ebadi and H.M. Brown-Borg. 2006. Ebselen effects on MPTP-induced neurotoxicity. Brain Research 1118:251-254.
Johnson, W.T., and H.M. Brown-Borg. 2006. Cytochrome c oxidase deficiency occurs in cardiac mitochondria during late postnatal heart development in progeny of copper-deficient dams. Experimental Biology and Medicine 231:172-180.
Tharakan, B., D. Muralikrishnan, H.M. Brown-Borg and B.V. Manyam. 2006. Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. Phytotherapy Research 20:165-168.
Brown-Borg, H.M. and J.C. Corton. 2006. PGC-1, calorie restriction and aging. American Aging Association Newsletter May 2006.
Ebadi, M., H.M. Brown-Borg, S. Sharma, S. Shavali, H. El ReFaey and E.C. Carlson. 2006. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Current Drug Targets 7:1513-1529.
Brown-Borg, H.M., and S.G. Rakoczy. 2005. Glutathione metabolism in long-living Ames dwarf mice. Experimental Gerontology 40(1-2):115-120.
Corton, J.C., and H.M. Brown-Borg. 2005. Peroxisome proliferator-activated receptor gamma co-activator 1 (PGC-1) in caloric restriction and other models of longevity. J. Gerontology: Biological Sciences 60A (12):1494-1509.
Brown-Borg, H.M., S.G. Rakoczy and E.O. Uthus, 2005. Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice. Mechanisms of Ageing & Development 126(3):389-398.
Stauber, A.J., H.M. Brown-Borg, J. Liu, M.P. Waalkes, A. Laughter, R.A. Staben, J.C. Coley, C. Swanson, K.A. Voss, J.J. Kopchick and J.C. Corton. 2005. Constitutive expression of peroxisome proliferator-activated receptor a-regulated genes in dwarf mice. Molecular Pharmacology 67(3):681-694.
Ebadi, M., S. Sharma, P. Ghafourifar, H. Brown-Borg and H. El ReFaey. 2005. Peroxynitrite in the pathogenesis of Parkinson’s disease and the neuroprotective role of metallothioneins. Methods in Enzymology 396:276-298.
Ebadi, M., H.M. Brown-Borg, H.El Refaey, B. Singh, S. Garrett, S. Shavali, and S.K. Sharma. 2005. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson’s disease. Brain Research: Molecular Brain Research 134:67-75.
Brown-Borg, H.M., S.G. Rakoczy and E.O. Uthus. 2004. Growth hormone alters components of the glutathione metabolic pathway in Ames dwarf mice. Annals of the New York Academy of Sciences 1019:317-320.
Brown-Borg, H.M. 2004. Antiaging supplement holds promise to halt age-related cognitive deterioration. Exp. Biol. Med. 229(5):367-368.
Fan, L.-Q., H. Brown-Borg, S. Brown, R.J. Edwards, and J.C. Corton. 2004. Regulation of phase I and phase II steroid metabolism enzymes by PPARa activators. Toxicology 204(2-3):109-121.
Fan, L.-Q., H. Brown-Borg, S. Brown, S. Westin, A. Mode, and J.C. Corton. 2004. PPARalpha activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase. Toxicology 203(1-3):41-48.
Esquifino, A.I., A. Arce, M.P. Alvarez, F. Chacon, H. Brown-Borg and A. Bartke. 2004. Differential effects of light/dark recombinant h-prolactin administration on the submaxillary lymph nodes and spleen activity of adult male mice. Neuroimmunomodulation 11(2):119-126.
Muralikrishnan, D., M. Ebadi and H.M. Brown-Borg. 2004. Dopamine agonist 3-PPP fails to protect against MPTP-induced toxicity. Neurochemical Research 29(2):379-384.
Romanick, M.A., S.G. Rakoczy and H.M. Brown-Borg. 2004. Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle. Mechanisms of Ageing Development 125(4):269-281.
Esquifino, A.I., A. Arce, M.P. Alvarez, V. Jimenez, H. Brown-Borg and A. Bartke. 2004. Light/dark h-prolactin effects on the submaxillary lymph nodes and spleen activity of Ames dwarf mice. Experimental Biology and Medicine (in press).
Brown-Borg, H.M. 2003. Hormonal regulation of aging and life span. Trends Endocrinol. Metab. 14(4):151-153.
Atwood, C.S., N. Barzilai, H.M. Brown-Borg, D.F. Jarrard, V.X. Fu, L.K. Heilbronn, D.K. Ingram, E. Ravussin, R.S. Schwartz and R. Weindruch. 2003. Pennington Scientific Symposium on Mechanisms and Retardation of Aging. Experimental Gerontology 38:1217-1226.
Uthus, E.O. and H.M. Brown-Borg. 2003. Altered methionine metabolism in long-living Ames dwarf mice. Experimental Gerontology 38:491-498.
Kennedy, M.A., S. G. Rakoczy and H.M. Brown-Borg. 2003. Long living Ames dwarf mouse hepatocytes readily undergo apoptosis. Experimental Gerontology 38:997-1008.
Brown-Borg, H.M., and S. G. Rakoczy. 2003. Growth hormone administration to long-living dwarf mice alters multiple components of the antioxidative defense system. Mechanisms of Ageing and Development 124:1013-1024.
Ren, J., Z.K. Roughead, F.L. Norby, S. Rakoczy, L.E. Wold, R.L. Mabey, and H.M. Brown-Borg. 2003. Increases in insulin-like growth factor-1 level and peroxidative damage after gestational ethanol exposure in rats. Pharmacological Research 47(4):341-347.
Esquifino, A.I., A. Arce, M.P. Alvarez, A. Szary, H. Brown-Borg and A. Bartke. 2002. Effects of overexpression of growth hormone on T cell activity in transgenic mice. J. Physiol. Biochem. 58(3):161-168.
Brown-Borg, H.M., S.G. Rakoczy, M.A. Romanick and M.A. Kennedy. 2002. Effects of growth hormone and insulin like growth factor-1 on hepatocyte antioxidative enzymes. Exp. Biol. Med. 227(2):94-104.
Muralikrishnan, D., M. Ebadi and H.M. Brown-Borg. 2002. Effect of MPTP on dopamine metabolism in Ames dwarf mice. Neurochemical Research 27(6):457-464.
Ren, J. and H. M. Brown-Borg. 2002. Impaired cardiac excitation-contraction coupling in ventricular myocytes from Ames dwarf mice with growth hormone/insulin-like growth factor I deficiency. Growth Hormone and IGF Research 12: 99-105.
Colligan, P.B., H.M. Brown-Borg, J. Duan, B.H. Ren and J. Ren. 2002. Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice. J. Endocrinology 173:257-264.
Brown-Borg, H.M., W.T. Johnson, S.G. Rakoczy and M.A. Romanick. 2001. Mitochondrial oxidant production and oxidative damage in Ames dwarf mice. J. Am. Aging Assoc. 24(3):85-96.
Bartke, A., H. Brown-Borg, J. Mattison, B. Kinney, S. Hauck and C. Wright. 2001. Prolonged longevity of hypopituitary dwarf mice. Experimental Gerontology 36(1):21-28.
Brown-Borg, H.M., and S.G. Rakoczy. 2000. Catalase expression in delayed and premature aging mouse models. Experimental Gerontology 35(2):199-212.
Bartke, A., H.M. Brown-Borg, B. Kinney, J. Mattison, C. Wright, S. Hauck, K. Coschigano and J. Kopchick. 2000. Growth hormone and aging. J. Am. Aging. Assoc. 23:219-225.
Brown-Borg, H.M., A. M. Bode and A. Bartke. 1999. Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process. Endocrine 11(1):41-48.
Dialynas, E., H.M. Brown-Borg and A. Bartke. 1999. Immune function in transgenic mice overexpressing growth hormone (GH) releasing hormone, GH or GH antagonist. Proc. Soc. Exp. Biol. Med. 221(3):178-183.
Bartke, A., H.M. Brown-Borg, A.M. Bode, J. Carlson, W.S. Hunter and R.T. Bronson. 1998. Does growth hormone prevent or accelerate aging? Experimental Gerontology. 33:675-687.
Brown-Borg, H.M., F. Blecha and H.G. Klemcke. 1997. Influence of plasma prolactin concentrations and age on neonatal immune function. Comp. Biochem. Phys. 118A(3):821- 829.
Brown-Borg, H.M., K.E. Borg, C.J. Meliska and A. Bartke. 1996. Dwarf mice and the aging process. Nature 384:33.
Brown-Borg, H.M., F.-P. Zhang, I. Huhtaniemi and A. Bartke. 1996. Developmental onset of prolactin receptor gene expression in fetal and neonatal mice. Eur. J. Endo. 134(6):751-757.
Esquifino, A.I., A. Szary, H.M. Brown-Borg and A. Bartke. 1996. Age-related effects of ectopic pituitary transplants on the activation of Ames dwarf mouse lymphocytes in vitro. Proc. Soc. Exp. Bio. Med. 211:87-93.
Klemcke, H.G., H.M. Brown-Borg and K.E. Borg. 1995. Functioning of the porcine pituitary-adrenocortical axis during neonatal development. Biology of the Neonate 67:274-286.
Borg, K.E., H.M. Brown-Borg and A. Bartke. 1995. Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mouse. Proc. Soc. Exp. Bio. Med. 210(2):126-133.
Brown-Borg, H.M., H.G. Klemcke and F. Blecha. 1993. Lymphocyte proliferative responses in neonatal pigs with high or low plasma cortisol concentration after stress induced by restraint. Am. J. Vet. Res. 54(12):2015-2020.
Brown-Borg, H.M., H.G. Klemcke, K.E. Borg and J. Klindt. 1993. Prolactin and growth hormone clearance in neonatal boars. J. Ani. Sci. 71:2055-2060.
Klemcke, H.G., D.D. Lunstra, H.M. Brown-Borg, K.E. Borg and R.K. Christenson. 1993. Association between low birthweight and increased adrenocortical function in neonatal pigs. J. Ani. Sci. 71:1010-1018.
Brown-Borg, H.M. and F.W. Edens. 1992. In vivo neurotoxin administration alters immune responses in chickens. Comp. Biochem. Phys. 102C(1):177-183.
Brown-Borg, H.M. and F.W. Edens. 1991. Tissue monoamine and plasma corticosterone concentrations following sympathetic alteration during acute endotoxicosis in chickens. Comp. Biochem. Phys. 99C(3):547-554.
Brown-Borg, H.M., F.W. Edens and P. Grant. 1991. Catecholamine- and endotoxin-influenced cutaneous basophil hypersensitivity in chickens. Comp. Biochem. Phys. 99C(3):541-545.
Edens, F.W., J.D. May, A.G. Yersin and H.M. Brown-Borg. 1991. Effect of fasting on plasma thyroid and adrenal hormone levels in turkey poults infected with Bordetella avium. Avian Dis. 35(2):344-347.
Beck, M.M., H.M. Brown-Borg and T.A. Jones. 1987. Peripheral and brainstem auditory function in paroxysmal (px) White Leghorn chicks. Brain Research 406:93-98.
Brown-Borg, H.M., M.M. Beck and T.A. Jones. 1987. Origins of peripheral and brainstem auditory responses in the White Leghorn chick. Comp. Biochem. Phys. 88A (3):391-396.
Jones, T.A., M.M. Beck and H.M. Brown-Borg. 1987. Far-field recordings of short latency auditory responses in the White Leghorn chick. Hearing Research 27(1):67-74.
Brown-Borg, H.M., M.M. Beck and T.A. Jones. 1986. Influence of stimulus polarity on auditory responses in the chick. J. Auditory Res. 26:255-260.
BOOKS, CHAPTERS, SPECIAL ISSUES
Brown-Borg HM, Borg KE. (eds). 2020. Special Issue: Proceedings of the Fourteenth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 15-20, 2018. Geroscience (online-various issues).
Brown-Borg HM, Anderson RM. (eds) 2017. Special Issue: Metabolism and Aging. Molecular and Cellular Endocrinology Issue 455.
Brown-Borg HM, Borg KE. (eds). 2017. Special Issue: Proceedings of the Thirteenth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17-22, 2016. Experimental Gerontology Vol 94 pp. 1-128.
Brown-Borg HM, Borg KE. (eds). 2015. Special Issue: Proceedings of the Twelfth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 27-August 1, 2014. Experimental Gerontology Vol 68 pp. 1-106.
Brown-Borg HM. 2014. Endocrinology of aging and longevity. Reference Module in Biomedical Sciences. Elsevier Press, Oxford. doi:10.1016/B978-0-12-801238-3.00151-3.
Brown-Borg HM, Borg KE. (eds.). 2013. Special Issue: Proceedings of the Eleventh International Symposium on Neurobiology and Neuroendocrinology of Aging. Experimental Gerontology Vol. 48 Issue 7 pp. 593-700.
Brown-Borg, H.M., Hale, B., Anderson, R., McCarter, R., Morley, J., Musi, N., Olshansky, J., St. Jacques, P., Walston, J. and Willcox, B. 2012. Nutrition in aging and disease: Update on the biological sciences. Aging Health 8(1):13-16.
Brown-Borg HM. 2011. Role of the somatotropic axis in mammalian aging. Chapter 2. In: Handbook of the Biology of Aging. Masoro, E., Austad, S. (eds). 7th Edition. pp 25-45.
Brown-Borg HM, Borg KE. (eds.). 2011. Special Issue: Proceedings of the Tenth International Symposium on Neurobiology and Neuroendocrinology of Aging. Experimental Gerontology Vol. 46 Issues 2-3.
Everitt A, Brown-Borg,HM, Le Couteur DG, Bartke A. 2010. Food Restriction, Hormones, Genes and Aging. Chapter 12. In: Calorie Restriction, Aging and Longevity. Eds. Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G., and de Cabo, R. Springer, New York, NY. pp. 217-232.
Everitt AV, L.K. Heilbronn, B. J. Morris, H.M. Brown-Borg, B.J. Merry, S.J. Simpson, K.A. Varady, E.J. Masoro, L.M. Redman, and D.G. Le Couteur. 2010. Conclusion: Human calorie restriction and anti-aging therapy. Chapter 18. In: Calorie Restriction, Aging and Longevity. Eds. Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G., and de Cabo, R. Springer, New York, NY. pp. 311-318.
Sell, C., Lorenzini, A., and Brown-Borg, H.M. (eds.) 2009. A Critical Analysis of Lifespan Extension: From Single Cell Organisms to Man. Humana Press, New York, NY.
Brown-Borg, H.M., Sharma, S., Borg, K.E., and Rakoczy S.G. 2009. Growth hormone and aging in rodents, Chapter 7 In: A Critical Analysis of Lifespan Extension. Eds. C. Sell , A. Lorenzini, and H.M. Brown-Borg. Humana Press, New York, NY. pp. 115-130.
Brown-Borg, H.M. 2005. Aging and Life Span. In: The Growth Hormone/Insulin-like Growth Factor Axis During Development. Advances in Experimental Medicine and Biology Eds. I.Varelo-Nieto, J.A. Chowen . Chapter 11. Springer, New York, NY. Volume 567 pp. 259-283.
Bartke, A. and H.M. Brown-Borg. 2004. Life extension in the dwarf mouse, In: Current Topics in Developmental Biology, Ed. G.P. Schatten. Chapter 6. Elsevier Academic Press, San Diego, CA. Volume 63 pp. 189-225.
Brown-Borg, H.M. and S.M. Harman. 2003. Hormones and Oxidative Stress, In: Oxidative stress and aging: advances in basic science, diagnostics, and intervention, Eds. R.G. Cutler and H. Rodriguez. Chapter 61, World Scientific Publishing , River Edge, NJ, pp. 1070-1119.
Invited Seminars/Presentations
Where we are understanding somatropic signaling and aging’
Presentation at the Robert and Arlene Kogod Center on Aging-Mayo Clinic Rochester
Rochester, MN
May 9, 2022
‘Somatotropic signaling, one carbon metabolism and aging’
Presentation at the 76th Annual Meeting of the Gerontological Society of America (Zoom)
Phoenix, AZ
November 13, 2021
‘The biology of aging: The promise of treating aging versus disease’
Presentation at UND SMHS Continuing Education Symposium
Grand Forks, ND
October 22, 2021
‘The role of reduced somatotropic signaling in aging and health’
Presentation at the NIH NIA Summer Training Course in Experimental Aging Research
Seattle, WA
8/30-9/4, 2021
‘Somatotropic signaling in health and disease’
Presentation at the University of Hawaii (Zoom)
John A. Burns School of Medicine
Honolulu, HI
June 7, 2021
‘Biology of Aging: Challenges and Research’
Presentation at the Grand Forks Rotary Club (Zoom)
Grand Forks, ND
April 27, 2021
‘Somatotropic signaling in health and disease’
Presentation at The Orentreich Foundation for the Advancement of Science (Zoom)
Cold Spring-on-Hudson, NY
February 9, 2021
‘Somatotropic signaling and healthy aging’
Presentation at the Huffington Center on Aging, Baylor University (Zoom)
Houston, TX
November 18, 2020
‘Challenges and opportunities in aging research’
Keynote Presentation at the 2019 UNESCO Anti-Aging Executive Committee Beijing Launch Conference & Second International Biomedical Health Annual Conference in China
Beijing, China
December 16, 2019
‘Somatotropic signaling and the epigenome’
Presentation at 2nd Institute on the Biology of Aging and Metabolism & 1st Midwestern Aging Consortium Symposia, University of Minnesota
Minneapolis, MN
November 5, 2019
‘Somatotropic signaling and metabolism: Impact on health and aging’
Keynote presentation at Symposium on Aging Research, University of Texas Health Consortium on Aging
Houston, TX
October 15, 2019
‘Somatotropic signaling and metabolism: Impact on health and aging’
Presentation at the Oklahoma Health Sciences Center, Center for Geroscience
Oklahoma City, OK
September 16, 2019
‘Travel Log: Developing your network’
Presentation at the 2019 Biomedical Graduate Retreat
Grand Forks, ND
September 7, 2019
Maintenance of a young epigenomic profile extends health and longevity’
Presentation at the 71st Annual Meeting of the Gerontological Society of America
Boston, MA
November 14-18, 2018
‘Slowing accelerated aging and disease: Genetic and dietary interventions’
Presentation at the 3rd International Conference on Aging and Disease
Nice, France
October 5-8, 2018
‘Somatotropic signaling and metabolism: Impact on health and aging’
Presentation at the Longevity Institute, University of Southern California
Los Angeles, CA
May 1, 2018
‘Endocrine manipulation in aging’
Presentation at the Keystone Symposium ‘Pushing the Limits to Healthspan and Longevity’
Hannover, Germany
April 16, 2018
‘Relationships between hormone signaling and aging via metabolism’
Presentation at Nebraska Redox Biology Symposium
Lincoln, NE
March 6, 2018
‘Somatotropic signaling is linked to health and aging via metabolism and the epigenome’
Presentation at Southern Illinois University Department of Geriatrics
Springfield, IL
December 8, 2017
‘Diet, body weight, hormones and longevity’
Presentation at the Obesity Society Annual Meeting
Washington, DC
October 31, 2017
‘Methionine metabolism and dementia’
Presentation at 2017 Symposium on Health Aging
Orentreich Foundation for the Advancement of Science
New Platz, New York
October 25-27, 2017
‘Somatotropic signaling is linked to health and aging via metabolism and the epigenome’
Presentation at the West Virginia University Blanchette Rockefeller Neurosciences Institute
West Virginia University Health Sciences Center
Morgantown, WV
September 20, 2017
‘Hormonal impact on measures of frailty and resilience’
Presentation at the 21st IAGG World Congress on Gerontology and Geriatrics
San Francisco, CA
July 24, 2017
‘Somatotropic signaling and aging: Impact on methionine metabolism and the epigenome’
Presentation at Max Planck Society Ringberg Castle/Director Linda Partridge Retreat
Kreuth, Germany
April 19-22, 2017
‘GH, methionine and methylation in long-living mice’
Presentation at the 2nd Interventions in Aging Conference
Cancun, Mexico
March 3, 2017
‘Metabolic adaptation to GH deficiency contributes to healthy aging’
Presentation at UND Department of Biology
Grand Forks, ND
February 10, 2017
‘Growth hormone impacts aging via methionine metabolism and DNA methylation’
Presentation at the University of Florida VA Geriatric Research Education and Clinical Center and Institute on Aging
Gainesville, FL
January 9, 2017
‘Metabolic adaptations to GH deficiency contribute to longer, healthy life’
Presentation at the 69th Annual Meeting of the Gerontological Society of America
New Orleans, LA
November 17, 2016
‘Growth hormone and metabolism: Contributions to health and lifespan’
Presentation at the International Symposium on Geroscience
Mexico City, Mexico
October 24-25, 2016
‘Somatotropic signaling, methionine metabolism and DNA methylation in aging.
Presentation at the 2nd International Conference on Aging and Disease
Li Ka Shing Learning & Knowledge Center, Stanford University
Palo Alto, CA
October 1-2, 2016
‘Biology of Aging Science: Challenges and Opportunities for the 21st Century’
Keynote Address at the Tenth Annual Division of Aging Biology New Investigators Forum
Natcher Conference Center, NIH National Institute on Aging
Bethesda, MD
June 29, 2016
‘Growth hormone, methionine and methylation: Aging lessons from mutant mice’
Presentation at the MDI Biological Laboratory Davis Center for Regenerative Biology & Medicine
Comparative & Experimental Approaches in Aging Biology Research course
Bar Harbor, ME
June 23, 2016
‘Linking methionine metabolism to aging: Role of hormones and diet’
Presentation at the University of Wisconsin Metabolism Colloquium
Morgridge Institute and Department of Nutritional Sciences
Madison, WI
May 18, 2016
‘Growth hormone, methionine & the epigenome: Are these factors linked to aging?
Presentation at the Mayo Clinic Robert and Arlene Kogod Center on Aging
Mayo Clinic
Rochester, MN
November 9, 2015
‘Impact of growth hormone on metabolism and the epigenome in aging’
Presentation at Molecular Biology of Ageing
Groningen, The Netherlands
October 27, 2015
‘Linking methionine metabolism to aging and longevity: Role of hormones and diet’
Presentation at Beatson Institute for Cancer Research
University of Glasgow
Glasgow, Scotland, UK
October 23, 2015
‘Impact of growth hormone on metabolism and epigenetics in aging’
Presentation at the University of Louisville CGeMM
Louisville, KY
October 13, 2015
‘Impact of dietary methionine on aging: Dependent on growth hormone status?’
Presentation at Symposium 2015: Diet, Sulfur Amino Acids, and Healthspan
Orentreich Foundation
Tarrytown, NY
September 21, 2015
‘The role of growth hormone in delayed aging: Impact of dietary intervention and epigenetics’
Presentation at University of Washington Basic Biology of Aging seminar series
Seattle, WA
April 16, 2015
‘Delayed aging: what we have learned from long-living mice’
Osher Lifelong Learning Institute
University of North Dakota
Grand Forks, ND
February 12, 2015
‘Growth hormone, methionine and methylation: Are these factors linked to longevity?’
Presentation at Oregon State University
Linus Pauling Institute Seminar Series
Corvallis, OR
January 15, 2015
‘Growth hormone and aging’
Presentation at The 2014 International Conference on Aging and Disease
Beijing, China
November 1-2, 2014
‘Growth hormone and methionine: Are these factors linked to aging and longevity?’
Keynote Lecture and Award at the Eurosymposium on Healthy Ageing
Brussels, Belgium
October 1, 2014
‘Methionine and methylation in GH mutant mice: Are these factors linked to aging and longevity?’
Presentation at the Biology of Human Aging Conference 2014
Parador de Oropesa, Spain
September 20, 2014
‘Linking methionine metabolism to aging and longevity: Role of hormones and diet’
Presentation at Auburn University, Harrison School of Pharmacy Auburn, AL
April 22, 2014
‘Growth hormone and methionine in aging and longevity’
Presentation at the Jackson Laboratory
Bar Harbor, ME
April 3, 2014
‘Linking methionine metabolism to aging and longevity: Role of hormones and diet’
Presentation at University of Arizona Center for Aging
Tucson, AZ
March 26, 2014
‘Linking methionine metabolism to aging and longevity: Role of hormones and diet’
Presentation at University of Texas Health Sciences Center-San Antonio
Barshop Institute for Longevity and Aging Studies
San Antonio, TX
February 24, 2014
‘Linking methionine metabolism to aging and longevity: Role of hormones and diet’
Consensus Workshop: Interventions to slow aging in humans: Are we ready?
Ettore Majorana Foundation and Centre for Scientific Culture
Erice, Sicily, Italy
October 9, 2013
‘Hormones and aging: Lessons from dwarf mice’
Lloyd Rolston Lecture Series
Altru Health System
Grand Forks, ND
September 18, 2013
‘Growth hormone and methionine: Interactions in aging and longevity’
Presentation at First International Symposium on Methionine Restriction and Longevity
Orentreich Foundation
Tarrytown, NY
September 9, 2013
‘Linking methionine to aging and disease: Diet, metabolism and hormones‘
Presentation at the 2013 Paul F. Glenn Symposium on the Biology of Aging
Aging Research and Chronic Disease Prevention
Santa Barbara, CA
June 6, 2013
‘Growth hormone and aging: The role of nutrient restriction or supplementation’
Symposium presentation at the 42nd Annual Meeting of the American Aging Association
Baltimore, MD
June 2, 2013
‘Lessons about aging and longevity from the Ames dwarf mouse’
Denham Harman Research Award Lecture at 42nd Annual Meeting of the American Aging Association
Baltimore, MD
June 2, 2013
‘DNA methylation in long-living mice‘
Presentation at Brown University, Department of Molecular Biology, Cell Biology & Chemistry
Providence, RI
April 18, 2013
‘Growth hormone and longevity assurance in mice’
Invited Lecturer at the Molecular Biology of Aging Course at the Marine Biological Laboratory
Woods Hole, MA
August 6, 2012
‘Growth hormone and aging: Does DNA methylation play a role?’
Presentation at 2nd International Conference on Genetics of Aging and Longevity
Moscow, Russia
April 23, 2012
‘The role of growth hormone and methionine metabolism in longevity’
Presentation at the Reynolds Oklahoma Center on Aging, University of Oklahoma Health Science Center
Oklahoma City, OK
March 29, 2012
‘Methionine metabolism and longevity’
Presentation at the University of North Texas Health Science Center Department of Pharmacology & Neuroscience
Fort Worth, TX
February 28, 2012
‘Growth hormone, methionine and aging’
Presentation at ‘Prevention and Intervention: From Molecular Biology to Clinical Perspectives’
Halle, Germany
September 17, 2011
‘Does atypical methionine metabolism contribute to longevity?’
Presentation at International Association of Biomedical Gerontologists/British Society for Research
on Aging
Brighton, England, UK
July 12, 2011
‘Growth hormone and aging: What we have learned from the Ames dwarf mouse’
Presentation at University of Minnesota Scientists in Aging Research Spring Symposium
Minneapolis, MN
April 15, 2011
‘Lessons from long-living mice: Growth hormone and stress resistance’
Presentation at Loyola University Medical Center Cell Biology, Neurobiology and Anatomy Program
Chicago, IL
March 31, 2011
‘Methionine metabolism in long-living mice’
Presentation at St. Johns University Department of Biological Sciences
Jamaica, NY
November 3, 2010
‘Methionine metabolism in long-living mice’
Presentation at the Orentreich Foundation for the Advancement of Science
Cold Spring-on-Hudson, NY
November 2, 2010
‘Spatial learning and memory in long-living Ames dwarf mice’
Presentation at the Gordon Research Conference on Biology of Aging
Les Diablerets, Switzerland
August 22, 2010
‘Role of growth hormone in thiol metabolism, stress resistance and aging’
Presentation at Fourth Annual Division of Biology New Investigators Forum
National Institutes of Health
Bethesda, MD
May 5, 2010
‘Growth hormone and aging: What we know and where do we go?’
Presentation for Grand Forks Chapter of PEO
Grand Forks, ND
April 4, 2010
‘Hormones and Long Life: Lessons from dwarf mice’
Presentation at University of North Dakota Faculty Lecture Series
Grand Forks, ND
January 21, 2010
‘Calorie restriction and metabolism in long-living mice’
Symposium presentation at 62nd Annual Meeting of the Gerontological Society of America,
Atlanta, GA
November 20, 2009
‘Role of Methionine in Aging and Longevity’
Presentation at University of North Dakota Department of Anatomy and Cell Biology
Grand Forks, ND
November 9, 2009
‘Role of Methionine in Aging and Longevity’
Presentation at SENS4: Strategies for Engineered Negligible Senescence,
Queen’s College, Cambridge, UK
September 3-7, 2009
‘Enhanced Defense Mechanisms in Long Living Mice’
Presentation at the Barshop Institute for Longevity and Aging Studies, University of Texas Health
Sciences Center
San Antonio, TX
October 22, 2008
‘Mechanisms of Resistance in Long Living Mice’
Keynote Address at 21st Annual American Federation for Aging Research Grantee Conference
Santa Barbara, CA
September 7, 2008
‘Enhanced Defense Mechanisms in Long Living Mice‘
Presentation at the Ninth International Symposium on Neurobiology and Neuroendocrinology of Aging, Kloster Mehrerau
Bregenz, Vorarlberg, Austria
July 23, 2008
‘Growth Hormone, Hormesis and Longevity in Mice’
Presentation at the 37th Annual Meeting of the American Aging Association
Boulder, CO
June 2, 2008
‘Longevity Mutants and Stress Resistance’
Symposium presentation at the 60th Annual Meeting of the Gerontological Society of America
San Francisco, CA
November 19, 2007
‘Growth Hormone and Life Span in Mammals’
Symposium presentation at the 89th Annual Meeting of the Endocrine Society,
Toronto, Ontario, Canada
June 3, 2007
‘Menopause and Hormone Therapy’
Presentation at University of North Dakota School of Medicine & Health Sciences Medical School for the Public Lecture Series
Grand Forks, ND
March 20, 2007
‘Growth Hormone, Insulin-Like Growth Factor 1 and Aging: Impact on Supercentenarians’
Presentation at Supercentenarian Research Foundation
Los Angeles, CA
February 24, 2007
‘The Role of Growth Hormone in Stress Resistance and Aging’
Presentation at North Dakota State University, Biological Sciences
Fargo, ND
November 3, 2006
‘Calorie Restriction Affects Brain Glutathione Metabolism in Normal and Long-Living Mice’
Presentation at the Eighth International Symposium on Neurobiology and Neuroendocrinology of Aging, Kloster Mehrerau
Bregenz, Vorarlberg, Austria
July 27, 2006
‘Mechanisms of Stress Resistance in Long-Living Mice’
Presentation at University of Konstanz
Konstanz, Germany
July 20, 2006
‘Expression of Peroxisome Proliferator-Activated Receptor a-regulated Genes in Dwarf Mice’
Presentation at the National Institutes of Health Nuclear Receptors and Aging Workshop
Potomac, MD
May 9, 2006
‘Glutathione Metabolism in Long-Living Mice’
Keynote presentation at University of Wisconsin –Biology of Aging and Age-Related Illnesses’
NIH Training Program
Madison, WI
April 6, 2006
‘Biology of Aging’ and ‘Antiaging medicine: Truth or Snake Oil Sales’
Presentations at University of North Dakota School of Medicine & Health Sciences Medical School for
the Public Lecture Series
Grand Forks, ND
March 21 & April 25, 2006
‘Longevity and Stress Resistance: Lessons from Dwarf Mice’
Presentation at University of New England Department of Pharmacology
Biddeford, ME
March 3, 2006
‘Life Style and Life Expectancy’
Invited Guest -“Today’s Odyssey on Health Show” Radio (KFYR) talk show presentation
January 23, 2006
‘Mechanisms of Stress Resistance in Long-Living Mice’
Presentation at University of North Dakota Department of Anatomy and Cell Biology
Grand Forks, ND
April 4, 2005
‘Ames Dwarf Mice, Oxidative Stress and Stress Resistance’
Presentation at the Buck Institute for Age Research
Novato, CA
February 11, 2005
‘Stress Resistance and Aging: Lessons from the Ames Dwarf Mouse’
Presentation at the University of North Dakota School of Medicine & Health Sciences Department of Pharmacology, Physiology and Therapeutics seminar series
Grand Forks, ND
February 4, 2005
‘Ames Dwarf Mice and Oxidative Stress’
Presentation at Gordon Research Conference on Biology of Aging
Aussois, France
September 12, 2004
‘Graduate Basic Science Programs in the School of Medicine and Health Sciences’
Presented at the Administrative Retreat – SMHS
Maplelag, MN
October 31, 2003
‘In vivo Growth Hormone Administration Alters Antioxidative Enzymes in GH-Deficient Mice.
Presented at Experimental Biology
San Diego, CA
April 12, 2003
‘Hormones and Aging: Lessons from Dwarf Mice’
Presented at the US Army Institute of Surgical Research
Ft. Sam Houston, TX
October 15, 2002
‘Growth Hormone and Aging: What We Are Learning From the Ames Dwarf Mouse’
Presented at the Aging Research & Education Center at the University of Texas Health Science Center
San Antonio, TX
August 6, 2002
‘Antioxidants and Methionine Metabolism in Long Living Mice’
Presented at the USDA Human Nutrition Research Center
Grand Forks, ND
May 28, 2002
‘What it Takes to Live a Long, Healthy Life’
Presented at Biomedical Research Foundations Seminar (BIMD 512), UND
Grand Forks, ND
October 19, 2001
‘Growth Hormone and Long Life: Lessons from Dwarf Mice’
Presented at North Dakota State University, Department of Animal Science
Fargo, ND
September 21, 2001
‘Growth Hormone and Long Life: Lessons from Dwarf Mice’
Presented at Endocrinology of Life-Span Extension Symposium
83rd Annual Meeting of the Endocrine Society
Denver, CO
June 19, 2001
‘Growth Hormone and Long Life: Lessons from Dwarf Mice’
Presented at University of North Dakota, Frank Low Research Day,
Grand Forks, ND
April 19, 2001
‘Longevity: Is Growth Hormone Involved or Not?’
Presented at the Kronos Longevity Research Institute
Phoenix, AZ
December 8, 2000
‘Longevity: Is Growth Hormone Involved or Not?’
Presented at University of North Dakota, Department of Anatomy and Cell Biology,
Grand Forks, ND
November 13, 2000
‘Growth Hormone and Aging Processes’
Presented at USDA Meat Animal Research Center
Clay Center, NE
March 27, 2000
‘Longevity: The Role of Growth Hormone’
Presented at University of North Dakota, Physiology 521 Seminar,
Fall 1998
‘Growth Hormone and Oxidative Enzyme Levels: Possible Role in the Aging Process’
Presented at Gordon Research Conference on Prolactin
Ventura, CA
February 4, 1998
‘Hormones and Cell Adhesion: Possible Role in Tumor Progression’
Presented at University of North Dakota, Sigma Xi Lecture Series,
Grand Forks, ND
November 1997
‘Molecule Expression in PRL-Dependent vs.-Independent Nb2 Lymphoma Cells’
Presented at the Joint North Dakota/South Dakota State EPSCoR Conference
Fargo, ND
September 26, 1997
‘The Role of Cell Adhesion Molecules and Prolactin in Cancer Metastasis’
Presented at University of North Dakota, Physiology 521 Seminar,
Grand Forks, ND
Fall 1996
‘The Effects of Prolactin on Immune Function’
Presented at University of North Dakota, Department of Physiology, School of Medicine,
Grand Forks, ND
November 1994
‘Prolactin and its Effects on Immunity’
Presented at Penn State University, Department of Veterinary Science
University Park, PA
November 8, 1994
‘Immunomodulation by the Neuroendocrine System’
Presented at University of Nebraska Medical Center, Department of Oral Biology
Lincoln, NE
June 10, 1994
‘Immunomodulation by the Neuroendocrine System’
Presented at Louisiana State University Medical Center,
Department of Pharmacology and Therapeutics, School of Medicine
Shreveport, LA
March 11, 1994
‘Prolactin and the Immune System’
Presented at University of Arkansas, Department of Poultry Science
Fayetteville, AR
December 20, 1993
Awards/Honors
NIH NIA Board of Scientific Counselors 2021-2026
2021 Endocrine Society New Frontiers in Basic Science Conference Moderator & Panel Discussant 2021
Appointed Assistant Dean for Gender Equity UND SMHS 2021-
UND SMHS Outstanding Unified Session III Instructor Award 2020-21
Elected Fellow of American Association for the Advancement of Science for distinguished contributions to the biology of aging 2018
UND 2018 Fellows of the University Award for Departmental Excellence in Research
UND SMHS Block 3 Instructor Award 2014, 2017, 2018, 2019, 2020
Keynote address-NIH National Institute on Aging-Division of Aging Biology New Investigators Forum 2016
Fellow of the American Aging Association 2016
Co-Organizer 2018 Keystone Symposium ‘Pushing the Limits to Healthspan and Longevity’
2015 Aging Cell journal Runner-Up Best Paper Prize for 2014
Distinguished Research Award; Eurosymposium on Healthy Ageing, Belgium 2014
American Aging Association Lifetime Achievement Denham Harman Research Award 2013
UND Foundation Thomas J. Clifford Faculty Achievement Award for Excellence in Research 2013
Glenn Award for Research in Biological Mechanisms of Aging 2011
Alpha Omega Alpha Medical Society – elected to faculty membership 2011
UND North Dakota Spirit Faculty Achievement Award 2011
UND Chester Fritz Distinguished Professor 2010
UND North Dakota Spirit Faculty Achievement Award 2010
UND Fellows of the University Award for Departmental Excellence in Research 2010
President - American Aging Association 2010-2011
Chair - Biological Sciences section of Gerontological Society of America 2010-2011
Chair International Symposium Neurobiology & Neuroendocrinology of Aging Austria 2009-present
Glenn Award for Research in Biological Mechanisms of Aging 2008
Chair-Gordon Research Conference on Biology of Aging (Switzerland) September 2007
UND Dean H. David Wilson Academic Award in Neurosciences 2007
Fellow of the Gerontological Society of America 2006
- Research Associate, Physiology, Southern Illinois University
- Research Associate, Endocrinology, USDA ARS MARC
- Ph.D., Physiology, North Carolina State University
- M.S., Animal Science, University of Nebraska-Lincoln
- B.S., University of Nebraska-Lincoln