Sarmad Al-Marsoummi

I'm interested in understanding human diseases and their pathological mechanisms. During my PhD work, I investigated the molecular mechanisms driving the aggressiveness and chemoresistance of breast and lung cancers. Currently, my research focuses on a broad spectrum of critical topics within clinical and translational sciences, including the implications of environmental factors such as arsenic and cadmium on human diseases, specifically in the development of urothelial bladder and kidney cancers.
Additionally, I'm working on understanding and characterizing kidney progenitor cells, investigating their role in the development of kidney diseases and cancers, and exploring the potential of using kidney progenitors to promote kidney repair after injuries.

• Al-Marsoummi S, Singhal S, Garrett SH, Somji S, Sens DA, Singhal SK. CD133+CD24+ Renal Tubular Progenitor Cells Drive Hypoxic Injury Recovery via Hypoxia-Inducible Factor-1A and Epidermal Growth Factor Receptor Expression. Int J Mol Sci. 2025 Mar 10;26(6):2472. doi: 10.3390/ijms26062472. PMID: 40141116; PMCID: PMC11942380.
  
  
• Ighofose E, Garrett SH, Al-Marsoummi S, Mehus AA, Sens DA, Singhal SK, Singhal S, Somji S. Effect of Long-Term Cisplatin Exposure on the Proliferative Potential of Immortalized Renal Progenitor Cells. Int J Mol Sci. 2024 Nov 22;25(23):12553. doi: 10.3390/ijms252312553. PMID: 39684265; PMCID: PMC11640886.
  
  
• Brown SR, Vomhof-DeKrey EE, Al-Marsoummi S, Beyer T, Lauckner B, Samson M, Sattar S, Brown ND, Basson MD. SLFN12 Expression Significantly Effects the Response to Chemotherapy Drugs in Triple-Negative Breast Cancer. Cancers (Basel). 2024 Nov 16;16(22):3848. doi: 10.3390/cancers16223848. PMID: 39594803; PMCID: PMC11593201.
  
  
• Al-Marsoummi S, Mehus AA, Garrett SH, Sens DA, Somji S. The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer. Cancers (Basel). 2024 Mar 17;16(6):1178. doi: 10.3390/cancers16061178. PMID: 38539513.
  
  
• Brown SR, Vomhof-DeKrey EE, Al-Marsoummi S, Brown ND, Hermanson K, Basson MD. Schlafen Family Intra-Regulation by IFN-α2 in Triple-Negative Breast Cancer. Cancers (Basel). 2023 Nov 30;15(23):5658. doi: 10.3390/cancers15235658. PMID: 38067362; PMCID: PMC10705374.
  
  
• Al-Marsoummi S, Mehus AA, Shrestha S, Rice R, Rossow B, Somji S, Garrett SH, Sens DA. Proteasomes Are Critical for Maintenance of CD133+CD24+ Kidney Progenitor Cells. Int J Mol Sci. 2023 Aug 27;24(17):13303. doi: 10.3390/ijms241713303. PMID: 37686107; PMCID: PMC10487892.
  
  
• Mehus AA, Jones M, Trahan M, Kinnunen K, Berwald K, Lindner B, Al-Marsoummi S, Zhou XD, Garrett SH, Sens DA, Sens MA, Somji S. Pevonedistat Inhibits SOX2 Expression and Sphere Formation but Also Drives the Induction of Terminal Differentiation Markers and Apoptosis within Arsenite-Transformed Urothelial Cells. Int J Mol Sci. 2023 May 23;24(11):9149. doi: 10.3390/ijms24119149. PMID: 37298099; PMCID: PMC10252886.
  
  
• Singhal, S.K.; Al-Marsoummi, S.; Vomhof-DeKrey, E.E.; Lauckner, B.; Beyer, T.; Basson, M.D. Schlafen 12 Slows TNBC Tumor Growth, Induces Luminal Markers, and Predicts Favorable Survival. Cancers 2023, 15, 402. https://doi.org/10.3390/cancers15020402. 
  
  
• Raafat Elsayed AA, Al-Marsoummi S, Vomhof-Dekrey EE, Basson MD. SLFN12 Over-expression Sensitizes Triple Negative Breast Cancer Cells to Chemotherapy Drugs and Radiotherapy. Cancer Genomics Proteomics. 2022 May-Jun;19(3):328-338. doi: 10.21873/cgp.20323. PMID: 35430566; PMCID: PMC9016483.
  
  
• Al-Marsoummi S, Vomhof-DeKrey EE, Basson MD. Schlafens: Emerging Proteins in Cancer Cell Biology. Cells. 2021 Aug 29;10(9):2238. doi: 10.3390/cells10092238. PMID: 34571887; PMCID: PMC8465726.
  
  
• Al-Marsoummi S, Pacella J, Dockter K, Soderberg M, Singhal SK, Vomhof-DeKrey EE, Basson MD. Schlafen 12 Is Prognostically Favorable and Reduces C-Myc and Proliferation in Lung Adenocarcinoma but Not in Lung Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 24;12(10):2738. doi: 10.3390/cancers12102738. PMID: 32987632; PMCID: PMC7650563.
  
  
• Al-Marsoummi S, Vomhof-DeKrey E, Basson MD. Schlafen12 Reduces the Aggressiveness of Triple Negative Breast Cancer through Post-Transcriptional Regulation of ZEB1 That Drives Stem Cell Differentiation. Cell Physiol Biochem. 2019;53(6):999-1014. doi: 10.33594/000000191. PMID: 31838790; PMCID: PMC7007982.
  
  
• Basson MD, Wang Q, Chaturvedi LS, More S, Vomhof-DeKrey EE, Al-Marsoummi S, Sun K, Kuhn LA, Kovalenko P, Kiupel M. Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation. Cell Physiol Biochem. 2018;48(3):1274-1290. doi: 10.1159/000492019. Epub 2018 Jul 25. PMID: 30045019; PMCID: PMC6123821.
  
  
• Al-Kaabi M, Hussam F, Al-Marsoummi S, Al-Anbaki A, Al-Salihi A, Al-Aubaidy H. Expression of ZO1, vimentin, pan-cadherin and AGTR1 in tanycyte-like cells of the sulcus medianus organum. Biochem Biophys Res Commun. 2018 Jul 12;502(2):243-249. doi: 10.1016/j.bbrc.2018.05.151. Epub 2018 May 26. PMID: 29803674.
  
  
• Al-Mufti F, Amuluru K, Changa A, Lander M, Patel N, Wajswol E, Al-Marsoummi S, Alzubaidi B, Singh IP, Nuoman R, Gandhi C. Traumatic brain injury and intracranial hemorrhage-induced cerebral vasospasm: a systematic review. Neurosurg Focus. 2017 Nov;43(5):E14. doi: 10.3171/2017.8.FOCUS17431. PMID: 29088959.
  
  
• Al-Mufti F, Smith B, Lander M, Damodara N, Nuoman R, El-Ghanem M, Kamal N, Al-Marsoummi S, Alzubaidi B, Nuoaman H, Foreman B, Amuluru K, Gandhi CD. Novel minimally invasive multi-modality monitoring modalities in neurocritical care. J Neurol Sci. 2018 Jul 15;390:184-192. doi: 10.1016/j.jns.2018.03.032. Epub 2018 Mar 28. PMID: 29801883.
  
  
• Huda R.K. Kamona, Zainab H.H. Al-Amily, Sarmad I. Al-Marsoummi. (2016, Jun). Evaluation of Intraplacental Villous Microvascular Density and Vascular Surface Area in Pregnancy Induced Hypertension and Its Correlation to Newborn Body Weight. Iraqi Journal of Medical Sciences, Vol 14(2), 112-118. ISSN 1681-6579 http://www.colmed-alnahrain.edu.iq http://www.iraqijms.net.
  
  
• Sarmad Al-Marsoummi, Alsalihi. (2015, Sep). Sexual differentiation of the spinal nucleus of Bulbo-Cavernosus Muscle (Onuf's nucleus). Iraqi Journal of Embryos and Infertility Research, Vol 5(Special Edition), 20-23: ISSN 2218-0265.